November 27, 2022
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New technology might help diagnose Alzheimer’s earlier

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Nearly 6.5 million Americans are living with Alzheimer’s.

There is no cure, few treatments, and it can only be found with an expensive scan or a painful spinal tap.

But now, researchers are testing a new device that may make testing easier. And that means it might lead to a diagnosis earlier.

John and Sylvia Whitley play Wordle every day. Today, the letters come easily but this couple knows that might not last. Ten years ago, the Whitley’s were caring for Sylvia’s mom with dementia and started noticing changes in themselves.

“Recalling names became more and more difficult over time,” John says.

“I saw one of my closest friends,” Sylvia recalls. “I saw her several times a week, and I had no idea what her name was.”

The couple had spinal fluid tests at Emory University. Sylvia had markers for Alzheimer’s. John did not. But after 58 years of marriage, each knew the other was struggling with memory. They both have had pet scans now. John was eligible for a clinical trial, testing a new way of detecting early signs of Alzheimer’s so, if needed, patients can begin treatment.

“I liken it to stopping a snowball before it starts getting rolling down the mountain,” said Dr. Richard Marshall from Progressive Medical Research in Port Orange, Fla.

The RetiSpec is an investigational device. It’s a special camera that can take 100 layered images of the retina.

“Then, they have artificial intelligence that reviews those images and can see the buildup of the amyloid plaque on the retina,” Dr. Marshall says.

Researchers are testing the RetiSpec’s accuracy. Earlier studies showed RetiSpec was between 80 and 90 percent accurate.

“If there’s anything out there that we can find for us, or and then to help other people, you know, we want to be part of it,” Sylvia says.

“Good for me, good for others,” John says.

Although Sylvia was not eligible for the test of the RetiSpec, she says her doctors are actively searching for other clinical trials in which she could be a participant. The researchers say the goal, after FDA approval, is to have the RetiSpec cameras installed in eye doctor’s offices, making the technology more widely available.

RESEARCH SUMMARY

TOPIC: RETISPEC DETECTS EARLY ALZHEIMER’S?

BACKGROUND: Approximately 5.8 million people in the United States age 65 and older have Alzheimer’s disease, eighty percent are 75 years or older and out of the fifty million people worldwide with dementia, between 60 and 70 percent are estimated to have Alzheimer’s disease. There is no known treatment that can cure Alzheimer’s or even alter the brain process of the disease and severe cases cause loss of brain function that can lead to someone not eating or drinking and leading to their death. (Source: https://www.mayoclinic.org/diseases-conditions/alzheimers-disease/symptoms-causes/syc-20350447)

DIAGNOSING: Alzheimer’s is a brain disease, and it causes a slow decline in memory, thinking and reasoning skills. Some warning signs with memory include memory loss that can disrupt your daily life, difficulty completing familiar tasks, trouble understanding visual images and spatial relationships or even new problems with words in speaking or writing. Some other symptoms of Alzheimer’s include getting lost in familiar places, misplacing possessions or putting them in illogical locations. (Source: https://www.alz.org/alzheimers-dementia/10_signs https://www.mayoclinic.org/diseases-conditions/alzheimers-disease/symptoms-causes/syc-20350447)

NEW TECHNOLOGY: RetiSpec is developing new technology to detect Alzheimer’s potentially years before any symptoms are even prevalent. While there is no current test that can confirm the actual diagnosis of Alzheimer’s, RetiSpec’s technology uses a device to perform a simple eye scan which is used to identify the presence of disease biomarkers in the eye and this technology also uses hyperspectral imaging techniques and AI-driven algorithmic methods to analyze the biomarker data. (Source: https://alzheimersnewstoday.com/news/retispec-gentex-developing-technology-detect-early-alzheimers/)



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